Recovery of renal tubule phosphate reabsorption despite reduced levels of sodium-phosphate transporter
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چکیده
منابع مشابه
Recovery of renal tubule phosphate reabsorption despite reduced levels of sodium-phosphate transporter.
BACKGROUND The acute effect of parathyroid hormone (PTH) on phosphate transport has been reported to be mediated by rapid downregulation of sodium-phosphate transporter (NaPi-IIa) protein, but the association was observed with pharmacological doses of PTH. OBJECTIVE To explore the effects of physiological doses of PTH on NaPi-IIa protein and its relationship to phosphate transport. METHODS ...
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In the kidney, approximately 80% of the filtered phosphate (Pi) is reabsorbed along the proximal tubule. Changes in renal Pi reabsorption are associated with modulation of the sodium-dependent Pi cotransporter type IIa (NaPi-IIa) and type IIc (NaPi-IIc) protein abundance in the brush-border membrane (BBM) of proximal tubule cells. NaPi-IIa is mainly regulated by dietary Pi intake and parathyroi...
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BACKGROUND The oxidative stress-responsive kinase 1 (OSR1) participates in the WNK-(with no K) kinase dependent regulation of renal salt excretion and blood pressure. Little is known, however, about the role of OSR1 in the regulation of further renal transport systems. The present study analyzed the effect of OSR1 on NaPiIIa, the major renal tubular phosphate transporter. METHODS Immunohistoc...
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AGUS, ZALMAN S., LAURENCE B. GARDNER, LAURENCE H. BECK, AND MARTIN GOLDBERG. Efects of parathyroid hormone on renal tubular reabsorption of calcium, sodium, and phosphate. Am. J. Physiol. 224(5) : 1143-l 148. 1973.-In order to study the relationships between sodium, calcium, and phosphate reabsorption in the proximal tubule and the effects of parathyroid hormone (PTH) on these relationships, re...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2004
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje.0.1510797